Efficacy of Dose-Escalated Radiotherapy for Recurrent Colorectal Cancer
Annals of Coloproctology
; : 66-72, 2016.
Article
in En
| WPRIM
| ID: wpr-215147
Responsible library:
WPRO
ABSTRACT
PURPOSE:
This study aimed to evaluate the effects of radiotherapy (RT) on progression-free survival (PFS) for patients with recurrent colorectal cancer.METHODS:
We reviewed the records of 22 patients with recurrent colorectal cancer treated with RT between 2008 and 2014. The median radiation dose for recurrent disease was 57.6 Gy (range, 45-75.6 Gy). Patients were divided into 2 groups according to the type of RT patients underwent RT without previous history of irradiation (n = 14) and those treated with secondary RT (reirradiation n = 8) at the time of recurrence.RESULTS:
The median follow-up period was 24.9 months (range, 4.5-66.6 months). Progression was observed in 14 patients (including 8 with loco-regional failure and 9 with distant metastases). Distant metastases were related to the RT dose (<70 Gy, P = 0.031). The 2-year loco-regional control (LRC), PFS, and overall survival (OS) rates were 74.6%, 45.1%, and 82.0%, respectively. The LRC rate was not different between the patients treated with RT for the first time and those treated with reirradiation (P = 0.101, 2-year LRC 79.5% vs. 41.7%). However, reirradiation was related to poor PFS (P = 0.022) and OS (P = 0.002). An escalated RT dose (≥70 Gy) was associated with a higher PFS (P = 0.014, 2-year PFS 63.5% vs. 20.8%).CONCLUSION:
Salvage RT for locally recurrent colorectal cancer can be offered when surgery is impossible. Dose-escalated RT shows a possible benefit in reducing the risk of progression.Key words
Full text:
1
Index:
WPRIM
Main subject:
Radiotherapy
/
Rectal Neoplasms
/
Recurrence
/
Colorectal Neoplasms
/
Follow-Up Studies
/
Disease-Free Survival
/
Neoplasm Metastasis
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Annals of Coloproctology
Year:
2016
Type:
Article