Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level / 대한통증학회지
The Korean Journal of Pain
; : 113-117, 2005.
Article
in Ko
| WPRIM
| ID: wpr-215230
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Serotonin 3 receptor is involved in the modulation of nociceptive transmission in the spinal cord. The serotonin 3 receptor antagonist has been used for the management of opioid-induced nausea and vomiting. The aim of this study was to examine whether the analgesic effect of morphine is antagonized by serotonin 3 receptor antagonists at the spinal level. METHODS: Rats were implanted with lumbar intrathecal catheters. For nociception, a formalin solution (5%, 50microliter) was injected into the hind paw of male Sprague-Dawley rats. To determine whether the effect of intrathecal morphine was mediated via serotonin 3 receptors, serotonin 3 receptor antagonists were intrathecally administered 10 min prior to the morphine delivery. Following the formalin injection, formalin-induced nociceptive behavior (flinching response) was observed for 60 min. RESULTS: Intrathecal morphine produced a dose-dependent suppression of the flinches in both phases during the formalin test. The analgesic action of morphine was not reversed by serotonin 3 receptor antagonists (LY-278, 584, ondansetron), which had little per se effect on the formalin-induced nociception. CONCLUSIONS: Spinal serotonin 3 receptors may not be involved in the analgesia of morphine on a nociceptive state evoked by a formalin stimulus.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Spinal Cord
/
Vomiting
/
Pain Measurement
/
Serotonin
/
Rats, Sprague-Dawley
/
Receptors, Serotonin, 5-HT3
/
Catheters
/
Nociception
/
Formaldehyde
/
Analgesia
Limits:
Animals
/
Humans
/
Male
Language:
Ko
Journal:
The Korean Journal of Pain
Year:
2005
Type:
Article