Chemical Pleurodesis Using Doxycycline and Viscum album Extract
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 281-286, 2017.
Article
in En
| WPRIM
| ID: wpr-217611
Responsible library:
WPRO
ABSTRACT
BACKGROUND: In chemical pleurodesis for managing pulmonary air leak, tetracycline derivatives are commonly used, and their effectiveness has been established in many studies. Recently, a Viscum album extract was used in chemical pleurodesis. We compared the effects of V. album with those of a tetracycline derivative (doxycycline) to demonstrate the therapeutic effectiveness of the V. album extract in chemical pleurodesis for managing pulmonary air leak. METHODS: Between October 2010 and October 2016, chemical pleurodesis was performed using doxycycline in 40 patients and the V. album extract in 37 patients. Thirty-three patients were in the postoperative state after pulmonary resection, and 44 patients suffered from spontaneous pneumothorax. RESULTS: No statistically significant difference in the success rate was observed between the 2 groups (V. album extract and doxycycline). In both groups, chest pain was the most common complication. More patients in the doxycycline group complained of severe chest pain (42.1% vs. 13.5%, p=0.006). In the V. album extract group, 24.3% of the patients required a chest tube to drain the pleural effusion after cessation of the air leak (doxycycline group: 5%, p=0.022). Further, the amount of pleural effusion drained on the day after the last chemical pleurodesis in the V. album extract group was greater than that in the doxycycline group (162.2±170.2 mL vs. 97.0±77.2 mL, p=0.032). All patients were discharged from the hospital without complications after pleural effusion drainage. CONCLUSION: Considering that treatment using the V. album extract was less painful, V. album might be a feasible option for chemical pleurodesis. However, pleural effusion should be monitored carefully when using V. album extract for treating patients suffering from air leak.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pleural Effusion
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Pneumothorax
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Tetracycline
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Chest Pain
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Chest Tubes
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Drainage
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Doxycycline
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Pleurodesis
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Viscum
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Viscum album
Limits:
Humans
Language:
En
Journal:
The Korean Journal of Thoracic and Cardiovascular Surgery
Year:
2017
Type:
Article