Changes in Expressions of Endothelin-1, Microphthalmia Associated Transcription Factor, and Protease-activated Receptor-2 after Ultraviolet Irradiation / 대한피부과학회지
Korean Journal of Dermatology
; : 1419-1424, 2004.
Article
in Ko
| WPRIM
| ID: wpr-220124
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
A number of cytokines, growth factors and inflammatory mediators made by keratinocytes, fibroblasts and potentially other cells in the skin were shown to augment melanin production and/or melanin transfer to keratinocytes. A lot of studies were done to investigate the mechanisms. But there was no studies about sequential relationship between the suggestive factors. OBJECT To measure the changes in expressions of ET-1, MITF, and PAR-2 after UV exposure on skin in Korean. MATERIAL ANDMETHOD:
We established an immunohistochemical staining protocol for specimens which were obtained from UV-irradiated skin in four healthy Korean males on the 2nd, 4th, 7th days after UV irradiation.RESULT:
This study reveals the sequential relationship between ET-1, MITF, and PAR-2. ET-1 was increased at day 2 and decreased at day 4 and 7. MITF increased gradually day 2, day 4, and day 7. PAR-2 increased at day 4 and increased once more at day 7.Key words
Full text:
1
Index:
WPRIM
Main subject:
Skin
/
Keratinocytes
/
Microphthalmos
/
Cytokines
/
Endothelin-1
/
Intercellular Signaling Peptides and Proteins
/
Microphthalmia-Associated Transcription Factor
/
Fibroblasts
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Melanins
/
Melanocytes
Limits:
Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
2004
Type:
Article