Activation of KRAS promotes the mesenchymal features of basal-type breast cancer
Experimental & Molecular Medicine
; : e137-2015.
Article
in En
| WPRIM
| ID: wpr-220405
Responsible library:
WPRO
ABSTRACT
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of mesenchymal phenotypes of basal-type breast cancer cells remain obscure. Here, we report that KRAS is a critical regulator for the maintenance of mesenchymal features in basal-type breast cancer cells. KRAS is preferentially activated in basal-type breast cancer cells as compared with luminal type. By loss and gain of KRAS, we found that KRAS is necessary and sufficient for the maintenance of mesenchymal phenotypes and metastatic ability through SLUG expression. Taken together, this study demonstrates that KRAS is a critical regulator for the metastatic behavior associated with mesenchymal features of breast cancer cells, implicating a novel therapeutic target for basal-type breast cancer.
Full text:
1
Index:
WPRIM
Main subject:
Phenotype
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Breast Neoplasms
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Gene Expression Regulation, Neoplastic
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Transcriptional Activation
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Cell Transformation, Neoplastic
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Proto-Oncogene Proteins
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Ras Proteins
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Cell Line, Tumor
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Disease Models, Animal
/
Gene Knockdown Techniques
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2015
Type:
Article