Urinary Angiotensinogen Excretion and Intrarenal Angiotensinogen Expression in Minimal Change Disease Patients / 대한신장학회지
Korean Journal of Nephrology
; : 593-600, 2011.
Article
in En
| WPRIM
| ID: wpr-220809
Responsible library:
WPRO
ABSTRACT
PURPOSE: Urinary angiotensinogen (AGT) has been reported as an important marker reflecting the activity of intrarenal renin-angiotensin system (RAS) in chronic glomerulonephritis patients. We investigated urinary AGT excretion and intrarenal AGT expression in patients with minimal change disease (MCD). METHODS: In 20 patients with biopsy-proven MCD, urinary and plasma AGT was measured using a sandwich ELISA and intrarenal AGT expression was measured with immunohistochemistry. Urine samples from normal healthy volunteers and patients with biopsy-proven thin basement membrane disease (TBM) were used as control groups. RESULTS: MCD patients showed a wide range of natural logarithm of the urinary AGT/creatinine [ln (urinary AGT/Cr)] and the ln (urinary AGT/Cr) was higher in MCD patients compared with normal controls and TBM controls (normal control vs. TBM vs. MCD, 1.2+/-0.25 vs. 0.9+/-0.34 vs. 3.2+/-0.40). Intrarenal AGT expression was diverse in MCD patients (intrarenal AGT, arbitrary unit, 27.39-78.52 in TBM, 0.00-145.80 in MCD). Ln (urinary AGT/Cr) did not show a direct correlation with intrarenal AGT expression, plasma AGT, or urinary protein/creatinine ratio. CONCLUSION: Urinary AGT excretion and intrarenal AGT expression are enhanced in some MCD patients, suggesting that intrarenal RAS is activated in these patients.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Proteinuria
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Renin-Angiotensin System
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Basement Membrane
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Enzyme-Linked Immunosorbent Assay
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Immunohistochemistry
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Angiotensinogen
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Corneal Dystrophies, Hereditary
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Glomerulonephritis
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Nephrosis, Lipoid
Limits:
Humans
Language:
En
Journal:
Korean Journal of Nephrology
Year:
2011
Type:
Article