Bupropion for Interferon-Alpha-Induced Depression in Patients with Hepatitis C Viral Infection: An Open-Label Study
Psychiatry Investigation
; : 142-145, 2015.
Article
in En
| WPRIM
| ID: wpr-221374
Responsible library:
WPRO
ABSTRACT
Interferon (IFN)-alpha therapy for chronic hepatitis C virus (HCV) infection is frequently associated with major depressive episodes. Bupropion, a commonly used antidepressant agent, has recently found to have strong anti-inflammatory effects in animal models. Despite of the theoretical relevancy, the antidepressant effect of bupropion in IFN-alpha-induced depression has never been studied. Ten HCV patients with IFN-alpha-induced depression were recruited to receive 8-week bupropion treatment and were assessed every 2 weeks for depressive symptoms by the Hamilton rating scale for depression (HAMD) and somatic symptoms by the Neurotoxicity Rating Scale (NRS). Four of the 10 patients met the criteria for remission (total HAMD scores< or =7), and 5 patients met the criteria for response (at least 50% reduction in total HAMD scores). In addition, 5 patients had 50% decreases in NRS for neuropsychiatric symptoms. This preliminary open-label study suggests that bupropion is effective in treating IFN-alpha-induced depressive and somatic symptoms.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Interferons
/
Bupropion
/
Hepatitis C
/
Hepatitis C, Chronic
/
Models, Animal
/
Depression
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Psychiatry Investigation
Year:
2015
Type:
Article