Interleukin-8 Expression in Psoriatic Skin of Different Disease Activities / 대한피부과학회지
Korean Journal of Dermatology
; : 339-345, 1999.
Article
in Ko
| WPRIM
| ID: wpr-222590
Responsible library:
WPRO
ABSTRACT
Psoriasis is a relatively common disorder that affects at least 1-2% of the population, however, the pathogenesis is not fully understood yet. Histopathologically, psoriatic lesion is characterized by hyperplasia of keratinocyte, intraepidermal neutrophil accumulation and activated T lymphocyte infiltration in the dermis. Among many cytokines, IL-8 is known to play a role for the activation and migration for neutrophil and T lymphocyte and for the proliferation of keratinocyte. We performed immunohistochemical staining with anti-IL-8 monoclonal antibody for the active lesion, stable lesion and normal-looking skin of ten psoriatic patients and ten healthy controls. Strong expression of IL-8 in the epidermis and dermis was noted from the active as well as stable psoriatic skins. In the normal-looking skin of the psoriatic patients, only faint expression which is not different from healthy control skin, was noted. These observations indicate that the expression of IL-8 is increased in psoriatic lesion, and IL-S is important for the initiation and maintenance of psoriasis.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Psoriasis
/
Skin
/
Lymphocytes
/
Keratinocytes
/
Cytokines
/
Interleukin-8
/
Dermis
/
Epidermis
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Hyperplasia
/
Neutrophils
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Dermatology
Year:
1999
Type:
Article