Prolonged Neutropenia after Sunitinib Treatment in a Patient with a Glucagonoma and Multiple Hepatic Metastases / 대한내과학회지
Korean Journal of Medicine
;
: 405-410, 2013.
Article
in Korean
| WPRIM
| ID: wpr-225747
ABSTRACT
Pancreatic neuroendocrine tumors (PNET) are rare, with approximately 2.2 in 1,000,000 people affected annually. In the classification of neuroendocrine tumors, glucagonomas are a functional PNET and comprise 1.6% of PNET. Glucagonoma syndrome is a paraneoplastic syndrome that is characterized by necrolytic migratory erythema, weight loss, anemia, and diabetes mellitus. Metastatic disease at presentation is common, but is often limited to the liver and regional lymph nodes. Sunitinib malate improves the progression-free and overall survival of PNET. This report presents a 45-year-old Asian woman with prolonged neutropenia after sunitinib treatment of a glucagonoma with multiple hepatic metastases. The severity of the neutropenia after the sunitinib treatment fluctuated from grade 1 to 4 repeatedly, with a non-febrile pattern. Ultimately, the patient did not recover from the neutropenia, even after stopping the sunitinib.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Paraneoplastic Syndromes
/
Pyrroles
/
Weight Loss
/
Neuroendocrine Tumors
/
Neuroectodermal Tumors, Primitive
/
Asian People
/
Diabetes Mellitus
/
Necrolytic Migratory Erythema
/
Glucagonoma
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2013
Type:
Article
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