Comparison of Cardiovascular Risk Profiles and Graft Function between Cyclosporin A-based and Tacrolimus-based Immunosuppression in Renal Transplant Recipients / 대한신장학회지
Korean Journal of Nephrology
; : 610-618, 2007.
Article
in Ko
| WPRIM
| ID: wpr-226304
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Tacrolimus (TAC) may be less unfavorable than cyclosporin A (CsA) on cardiovascular morbidity and mortality in renal transplant recipients, but well controlled studies are insufficient.METHODS:
In this prospective randomized controlled study, fifty seven consecutive renal transplant recipients were treated with CsA-based (CsA, MMF and steroid, CsA group n=27) or TAC-based (TAC, MMF and steroid, TAC group n=30) immunosuppressive regimens by randomized ratio of 11. In the baseline (pre-operation), 1, 3, and 6 months after transplantation, several cardiovascular risk factors and graft function were evaluated.RESULTS:
There were no significant differences in the renal function, glucose regulation, the incidence of acute rejection and post-transplant diabetes mellitus for the post-transplant 6 months between the two groups. The blood pressure of the CsA group was maintained higher than TAC group through 6 months after transplantation even though the number of antihypertensive drugs in the CsA group was significantly higher at 3 and 6 month after transplantation. The lipid profiles except oxidized LDL were similar, but oxidized LDL level was significantly higher for the post-transplant 6 months in the CsA group (p<0.05). There were no significant differences in levels of fibrinogen, PAI-I, t-PA, hs-CRP, homocysteine, spot urine TGF-beta a and beta ig-h3, but the uric acid level was significantly higher in the CsA group (p<0.05).CONCLUSION:
This study demonstrates that TAC tends to have a beneficial effect on cardiovascular risk profiles, with regard to BP and atherogenic properties of serum lipids in early post-transplant period.Key words
Full text:
1
Index:
WPRIM
Main subject:
Transplantation
/
Uric Acid
/
Blood Pressure
/
Fibrinogen
/
Cardiovascular System
/
Incidence
/
Prospective Studies
/
Risk Factors
/
Mortality
/
Transforming Growth Factor beta
Type of study:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
Ko
Journal:
Korean Journal of Nephrology
Year:
2007
Type:
Article