Complement-fixing abilities and IgG subclasses of autoantibodies in epidermolysis bullosa acquisita
Yonsei Medical Journal
; : 339-344, 1998.
Article
in En
| WPRIM
| ID: wpr-229297
Responsible library:
WPRO
ABSTRACT
Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Autoantibodies
/
Complement System Proteins
/
Immunoglobulin G
/
Epidermolysis Bullosa Acquisita
/
Fluorescent Antibody Technique
/
Middle Aged
Limits:
Adult
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Female
/
Humans
/
Male
Language:
En
Journal:
Yonsei Medical Journal
Year:
1998
Type:
Article