Polymorphism of the human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 586-588, 2007.
Article
in Zh
| WPRIM
| ID: wpr-229864
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the polymorphism of human platelet alloantigens HPA-3 and HPA-9w in the Chinese Han population.</p><p><b>METHODS</b>A total of 1000 unrelated Chinese Han blood donors from different provinces of China were genotyped for HPA-3 and HPA-9w using PCR-sequence specific primer assay.</p><p><b>RESULTS</b>Gene frequencies of 1000 Chinese Hans for HPA-3a and HPA-3b were 0.5935 and 0.4065 respectively, and all of them were HPA-9a positive. The distributions of HPA-3, HPA-9w of Chinese Hans which detected by chi-square criterion fit Hardy-Weinberg equilibrium. There were significant differences of the HPA-3 alleles gene frequency between Guangdong province and other five investigated provinces which included Shanxi, Heilongjiang, Zhejiang, Yunnan and Jiangsu. In comparison to other ethnic groups, no significant differences were observed in the distributions of HPA-3 except the Vietnamese and Australian.</p><p><b>CONCLUSION</b>The results show that the chance of HPA-3 incompatibility were 0.3661 in random transfusion, and also provide a basis for researching on alloimmune thrombocytopenia and HPA-matched transfusion.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
/
DNA
/
Ethnicity
/
China
/
Antigens, Human Platelet
/
Asian People
/
Alleles
/
Allergy and Immunology
/
Ethnology
/
Gene Frequency
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2007
Type:
Article