Effect of bushen antai recipe and its various compositions on endometrial sexual hormones and receptors in mice with blastocyst implantation dysfunction / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 291-294, 2010.
Article
in Zh
| WPRIM
| ID: wpr-231537
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the effects and mechanisms of Bushen Antai Recipe (BAR) and its different compositions, Bushen Recipe (BSR, the Shen-nourishing part) and Huoxue Recipe (HXR, the blood-activating part) on the endometrial receptivity in mice with blastocyst implantation dysfunction (BID).</p><p><b>METHODS</b>Model mice of BID induced by indomethacin were treated respectively with BAR, BSR and HXR from the first day of pregnancy, and killed on day 5 or 6. Samples of their serum and uterine were collected for detecting serum estradiol (E2), progesterone (P) contents using radioimmunoassay; and endometrial expression levels of their receptors, ER and PR, using immunohistochemistry.</p><p><b>RESULTS</b>Serum levels of E2 and P, and endometrial expression of ER and PR increased significantly on day 6 in mice after treated by BAR, but in those treated by BSR and HXR, the improvements were significantly lesser.</p><p><b>CONCLUSION</b>BAR, by combined application of both Shen-nourishing and blood-activating methods, could impact E2, P, ER and PR to improve the endometrial receptivity to a higher extent in BID mice so as to promote embryo implantation.</p>
Full text:
1
Index:
WPRIM
Main subject:
Embryo Implantation
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Pharmacology
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Progesterone
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Blood
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Drugs, Chinese Herbal
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Receptors, Progesterone
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Receptors, Estrogen
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Endometrium
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Estradiol
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Metabolism
Limits:
Animals
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Pregnancy
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2010
Type:
Article