Neurotransmitter-precursor-supplement intervention for detoxified heroin addicts / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 422-427, 2012.
Article
in En
| WPRIM
| ID: wpr-233142
Responsible library:
WPRO
ABSTRACT
This study examined the effects of combined administration of tyrosine, lecithin, L-glutamine and L-5-hydroxytryptophan (5-HTP) on heroin withdrawal syndromes and mental symptoms in detoxified heroin addicts. In the cluster-randomized placebo-controlled trial, 83 detoxified heroin addicts were recruited from a detoxification treatment center in Wuhan, China. Patients in the intervention group (n=41) were given the combined treatment with tyrosine, lecithin, L-glutamine and 5-HTP and those in the control group (n=42) were administered the placebo. The sleep status and the withdrawal symptoms were observed daily throughout the study, and the mood states were monitored pre- and post-intervention. The results showed that the insomnia and withdrawal scores were significantly improved over time in participants in the intervention group as compared with those in the control group. A greater reduction in tension-anxiety, depression-dejection, anger-hostility, fatigue-inertia and total mood disturbance, and a greater increase in their vigor-activity symptoms were found at day 6 in the intervention group than in the control group (all P<0.05). It was concluded that the neurotransmitter-precursor-supplement intervention is effective in alleviating the withdrawal and mood symptoms and it may become a supplementary method for patients' recovery from heroin addiction.
Full text:
1
Index:
WPRIM
Main subject:
Substance Withdrawal Syndrome
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Therapeutics
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Placebo Effect
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Single-Blind Method
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Administration, Oral
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Treatment Outcome
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Neurotransmitter Agents
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Dietary Supplements
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Diagnosis
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Drug Therapy
Type of study:
Clinical_trials
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Diagnostic_studies
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Year:
2012
Type:
Article