Mutation analysis of ATP2C1 gene in a Chinese family with Hailey-Hailey disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 414-416, 2010.
Article
in Zh
| WPRIM
| ID: wpr-234393
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study a Chinese pedigree with Hailey-Hailey disease (HHD) and identify the ATP2C1 gene mutation in this family.</p><p><b>METHODS</b>All exons of the ATP2C1 gene were analyzed with polymerase chain reaction and DNA sequencing in all patients of this family and 80 unrelated population-matched controls.</p><p><b>RESULTS</b>We identified a nonsense mutation 163C to T, resulting in a premature termination codon in ATP2C1 gene. The mutation was not found in normal individuals of the family and controls.</p><p><b>CONCLUSION</b>The mutation can affect the result of transcription and translation of ATP2C1 gene, and it is firstly reported in the Chinese pedigree with HHD.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pedigree
/
DNA Mutational Analysis
/
Pemphigus, Benign Familial
/
Calcium-Transporting ATPases
/
Asian People
/
Genetics
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Medical Genetics
Year:
2010
Type:
Article