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Effect of neurotrophin p75 receptor activation on transmural dispersion repolarization in rabbits with myocardial infarction / 中国应用生理学杂志
Article in Zh | WPRIM | ID: wpr-235386
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the effect of neurotrophin p75 receptor (p75NTR)on transmural dispersion repolarization (TDR) of the layers of left ventricular myocytes in rabbits with myocardial infarction (MI).</p><p><b>METHODS</b>Forty Japanese rabbits were divided into four groups (n = 10): (1) Sham group, (2) Heald myocardial infarction (HMI) group, (3) p75 NTR activation group, (4) p75 NTR inhibition group. Cardiomyocytes were isolated with enzyme digestion and the currents were recorded by whole-cell patch-clamp technique.</p><p><b>RESULTS</b>Compared with those in the sham group, the duration of 90% action potential repolarization (APD90) and transmural dispersion repolarization of three layers of left ventricular myocytes were obviously raised (P < 0.05). But significant reduction was observed in p75NTR(-) group. Current densities of Ito and I(Ks, tail) in the p75NTR(+) group and HMI group were significantly reduced (P < 0.05), especially in mid myocytes. And no obvious changes were observed in p75NTR(-) group.</p><p><b>CONCLUSION</b>Activation of p75NTR(+) increases transmural dispersion repolarization, which may lead to the incidence of arrhythmia.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Physiology / Arrhythmias, Cardiac / Patch-Clamp Techniques / Receptor, Nerve Growth Factor / Myocytes, Cardiac / Heart Ventricles / Membrane Potentials / Metabolism / Myocardial Infarction Limits: Animals Language: Zh Journal: Chinese Journal of Applied Physiology Year: 2013 Type: Article
Full text: 1 Index: WPRIM Main subject: Physiology / Arrhythmias, Cardiac / Patch-Clamp Techniques / Receptor, Nerve Growth Factor / Myocytes, Cardiac / Heart Ventricles / Membrane Potentials / Metabolism / Myocardial Infarction Limits: Animals Language: Zh Journal: Chinese Journal of Applied Physiology Year: 2013 Type: Article