Hyperglycemic effects of a periocular dexamethasone injection in diabetic patients after vitreoretinal surgery / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 311-316, 2012.
Article
in En
| WPRIM
| ID: wpr-235553
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To examine the hyperglycemic effects of periocular dexamethasone injection in type 2 diabetic patients after vitreoretinal surgery (VRS).</p><p><b>METHODS</b>This was a retrospective non-randomized controlled trial. Twenty consecutive hospitalized patients with type 2 diabetes and ocular inflammatory reaction after VRS were enrolled in this study. Ten patients received 2.5 mg dexamethasone and 10 patients received 5 mg dexamethasone. Fourteen consecutive type 2 diabetic patients without ocular inflammatory reaction after VRS were used as control group. We measured fasting blood glucose (FBG) and at 2 h after each meal (post prandial glucose, PBG; 0900, 1300, and 1900 h) after periocular dexamethasone injection. Differences among three groups were determined by q tests.</p><p><b>RESULTS</b>The PBG levels in both dexamethasone-treated groups started to increase within 5 h after injection (i.e., PBG at 1300 h), and were significantly increased at 1900 h after injection (P<0.05). BG levels were almost 2-fold higher than at baseline and compared with the control group. The BG values declined gradually by 24 h to 48 h after injection. There were no differences in BG levels between the two dexamethasone-treated groups (P>0.05), except for PBG at 1900 h on day 2 after injection (P<0.05).</p><p><b>CONCLUSION</b>Periocular dexamethasone injection can cause transient hyperglycemia in diabetic patients after VRS. BG monitoring should be performed following such injection.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
/
Dexamethasone
/
Retrospective Studies
/
Diabetes Mellitus, Type 2
/
Injections, Intraocular
/
Vitreoretinal Surgery
/
Hyperglycemia
/
Anti-Inflammatory Agents
Type of study:
Observational_studies
Limits:
Humans
Language:
En
Journal:
Biomedical and Environmental Sciences
Year:
2012
Type:
Article