Effect of Shugan Jianpi Granule () on gut mucosal serotonin-positive cells in patients with irritable bowel syndrome of stagnated Gan-qi attacking Pi syndrome type / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 185-189, 2008.
Article
in En
| WPRIM
| ID: wpr-236270
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of Shugan Jianpi Granule (, SJG) on the number of gut mucosal serotonin-positive cells (5-HT+C) in patients with irritable bowel syndrome (IBS) of stagnated Gan-qi attacking Pi (SGAP) syndrome type.</p><p><b>METHODS</b>Twenty-four patients were randomized equally into three groups. All were treated with the basic conventional treatment by cognition-behavior therapy with assistance of lactein 3 tablets thrice a day. Additionally, 24 g of SJG was given three times a day to group A, and the same dosage of SJG and Smecta 15 g thrice a day was given to group B, while no additional treatment was given to the control group. The number of 5-HT+C was measured respectively before and two weeks after treatment by immunohistochemical method.</p><p><b>RESULTS</b>The number of 5-HT+C decreased after treatment in all the three groups (P<0.05), but the decrement was more significant in the two test groups than in the control group (P<0.05 and P<0.01, respectively), while comparison of 5-HT+C between the two test groups showed insignificant difference (P>0.05).</p><p><b>CONCLUSION</b>SJG can reduce the number of 5-HT+C in IBS patients of SGAP syndrome type, and its effect is enhanced when used in combination with Smecta.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Pharmacology
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Syndrome
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Drugs, Chinese Herbal
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Immunohistochemistry
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Serotonin
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Cell Count
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Irritable Bowel Syndrome
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Therapeutic Uses
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Drug Therapy
Type of study:
Clinical_trials
/
Diagnostic_studies
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
Chinese journal of integrative medicine
Year:
2008
Type:
Article