Changes of pathogens for nosocomial infection of patients with hematological diseases / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1031-1035, 2010.
Article
in Zh
| WPRIM
| ID: wpr-237601
Responsible library:
WPRO
ABSTRACT
In order to investigate the distribution of nosocomial infection in patients with hematological diseases in our hospital, and to explore the changes of the pathogens isolated. The method of retrospective investigation and analysis was employed. 1164 strain pathogens were isolated from the patients with hematological diseases during the period of 1997-2009. The results showed that the Gram-positive cocci infection increased gradually during the 13 years, but has been stable in the last 4 years. The Gram-negative bacteria showed a trend decrease. The fungi increased during these years. The rates of infection with gram-positive cocci, gram-negative bacteria and fungus were 28.2%, 59.8% and 12.0% respectively. For the details, Escherichia coli infection rate was the highest 12.1%, followed by Pseudomonas aeruginosa (9.1%), Enterobacter (8.4%), Klebsiella pneumoniae (7.4%), Staphylococcus epidermidis (6.3%) and Enterococci (6.6%). The distribution of G(+)- and G⁻ pathogens showed obvious change on end of 1990's and beginning of this century, but it was tending towards stability on recent years; the incidence of fungus was tending towards increase, which was related to wide application of strong broad-spectrum antibiotics. In conclusion, the patients with hematological diseases, as the high-risk group of nosocomial infection, should be monitored strictly. Infection is related to many factors, and the main factor is dysfunction of autoimmunity. The strategies should be explored to strengthen the immune protection and set up a reasonable scheme of antibiotics.
Full text:
1
Index:
WPRIM
Main subject:
Bacterial Infections
/
Cross Infection
/
Epidemiology
/
Incidence
/
Gram-Positive Bacterial Infections
/
Gram-Negative Bacterial Infections
/
Escherichia coli
/
Hematologic Diseases
/
Microbiology
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article