Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3444-3449, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-237691
ABSTRACT
Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Drugs, Chinese Herbal
/
Receptors, Steroid
/
Gene Expression
/
Drug Evaluation, Preclinical
/
Genetics
/
Metabolism
Type of study:
Diagnostic study
/
Screening study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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