Primary Intraosseous Malignant Fibrous Histiocytoma of the Skull: A Case Report
Journal of Korean Medical Science
;
: 609-613, 2003.
Article
in English
| WPRIM
| ID: wpr-23951
ABSTRACT
Malignant fibrous histiocytoma(MFH) is a rare primary neoplasm that constitutes less than 1% of the malignant tumors of bone, and involvement of the skull is very rare. We present a case of malignant fibrous histiocytoma of the skull, presenting an intraosseous lesion in a 43-yr-old woman. She had a rapidly growing, tender mass in the right parietal region. A plain radiograph showed an osteolytic lesion of the right parietal bone. Magnetic resonance imaging revealed that the lesion showed heterogeneous low signal intensity on T1-weighted images and slightly high signal intensity on T2-weighted images. No evidence of an extraosseous extension to the adjacent dura and soft tissue was found, and a wide excision of the parietal bone was performed. Histologically, the tumor was a typical MFH displaying pleomorphic spindle cells in a storiform pattern. The results of immunohistochemical stainings revealed that the tumor cells were positive for vimentin, alpha-1-antitryp-sin, and p53, and negative for smooth muscle actin, S100 protein, desmin, and MyoD1. Three months later, a mainly cystic, recurrent mass was developed at the previously operated site. Before the resection, we first performed the percutaneous aspiration cytology, revealing diagnostic multinucleated pleomorphic cells. There-after, she had to receive repetitive resections of recurrent or residual lesions, and she died of postoperative meningoencephalitis two years after the first operation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skull Neoplasms
/
Vimentin
/
Brain
/
Immunohistochemistry
/
Magnetic Resonance Imaging
/
S100 Proteins
/
Tomography, X-Ray Computed
/
Giant Cells
/
Alpha 1-Antitrypsin
/
Tumor Suppressor Protein p53
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2003
Type:
Article
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