Reasearch progress on the role of neutrophils in asthma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 544-549, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-239551
ABSTRACT
Asthma is a phenotypically heterogeneous chronic disease of the airways. Studies have found that neutrophils are crucial to airway inflammation in acute asthma, persistent asthma, particularly in asthma of poor response to glucocorticoid treatment. The role of neutrophils in development of bronchial asthma is complex, as they can release a potent source of cytokines and inflammatory mediators participating in asthma. Differing from eosinophilic inflammatory asthma, neutrophilic inflammatory asthma is not depend on helper T (Th)2 cells, but may be related to Th1 and Th17 cells. This review highlights the role of neutrophils in the development of asthma, and the treatment of neutrophilic asthma with biological agents and novel small molecules.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Asthma
/
Therapeutics
/
Cytokines
/
Th1 Cells
/
Allergy and Immunology
/
Th17 Cells
/
Inflammation
/
Neutrophils
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2016
Type:
Article
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