The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.</p><p><b>METHOD</b>Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.</p><p><b>RESULTS</b>The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).</p><p><b>CONCLUSION</b>HPCD is an ideal solubilizer for paeonolum.</p>