Clinical study on acute kidney injury after myeloablative allogeneic hematopoietic cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 401-404, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-240004
ABSTRACT
<p><b>OBJECTIVE</b>To explore the incidence, pathogenesis, risk factors, prophylaxis and treatment of acute kidney injury (AKI) after myeloablative allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>Clinical data of 120 patients received myeloablative allo-HSCT were retrospectively analyzed.</p><p><b>RESULTS</b>Serum creatinine level in the patients showed significantly higher than baseline value at 28-60 days after transplantation (P<0.05). 73 patients (60.8%) developed AKI at a median of 33 days after allo-HSCT, including grade 2 in 32 patients (26.7%). Patients with grade 1 AKI showed significant higher serum cyclosporine A (CsA) levels (P<0.05). Hepatic veno-occlusive disease( HVOD), acute graft-versus-host disease (aGVHD) and total bilirubin > 40 micromol/L were high risk factors of occurring AKI (P<0.05). 19 patients died within 100 days after allo-HSCT, grade 2 AKI was a high risk factor of mortality (P< 0.05). 180-day survival rate was significantly lower in patients with grade 2 AKI after allo-HSCT (P<0.05).</p><p><b>CONCLUSION</b>AKI is one of the major complications after myeloablative allo-HSCT. Prophylaxis and treatment of AKI might reduce mortality in early stage of transplantation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Complications
/
Transplantation, Homologous
/
Retrospective Studies
/
Risk Factors
/
Hematopoietic Stem Cell Transplantation
/
Transplantation Conditioning
/
Acute Kidney Injury
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2008
Type:
Article
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