Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the differential expression of homeobox genes in the normal, wounded human fetal and adult skins and its significance in fetal scarless healing.</p><p><b>METHODS</b>Gene chips containing 14 000 human genes were used to investigate homeobox gene expressions of the normal, wounded human fetal and adult skins.</p><p><b>RESULTS</b>There were significant differences between the expression of homeobox genes, especially for PRX-2, HOXB13, HOXB6 and HOXB7.</p><p><b>CONCLUSIONS</b>The homeobox gene is in close relation to developmental biology. The different expressions and changes of homeobox genes in the normal, wounded human fetal and adult skin may be a primary cause of different wound healing between fetal and adult skin.</p>