Transitional CK19 positive cells-a new possible marker of hepatic precancerous lesion / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 38-39, 2004.
Article
in Zh
| WPRIM
| ID: wpr-240516
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between Transitional CK19 positive cells and hepatic precancerous lesion in chronic hepatitis B patients.</p><p><b>METHODS</b>We observed the expression of CK19 in liver tissue of chronic hepatitis B patients by LSAB immunohistochemical staining, and examined serum AFP and ultrasonography one time per 3 months for one year.</p><p><b>RESULTS</b>We observed a population of CK19 positive cells-with size and structure between those of human oval cells and mature hepatocytes-that usually occurred along with oval-cell proliferation. It was suggested that these transitional cells may partly account for the elevation of serum AFP. One patient occurred hepatic carcinoma, another patient had low-echogenic nodules in liver parenchyma within the 1 year follow-up period.</p><p><b>CONCLUSION</b>Transitional CK19 positive cells could be regarded as a new possible pathological marker of hepatic precancerous lesion.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Precancerous Conditions
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Alpha-Fetoproteins
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Biomarkers, Tumor
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Tomography, X-Ray Computed
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Chemistry
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Keratins
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Liver Neoplasms
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2004
Type:
Article