ZnPP IX and L-NAME reduce the cGMP content in the penile tissue of rats / 中华男科学杂志
National Journal of Andrology
; (12): 523-525, 2009.
Article
in Zh
| WPRIM
| ID: wpr-241308
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of CO release inhibitor zinc protoporphyria IX (ZnPP IX) and NO release inhibitor L-NAME on the content of cGMP in the penile tissue of rats.</p><p><b>METHODS</b>Thirty Wistar rats were randomly divided into a normal control, a ZnPP IX, and an L-NAME group, given saline (1 ml/kg/d), ZnPP IX (45 micromol/kg/d) and L-NAME (50 mg/kg/d), respectively, for 7 days. Then all the rats were killed, homogenate made from their penile tissues and detected for the contents of NOS, NO, CO and cGMP.</p><p><b>RESULTS</b>The contents of CO, NOS, NO and cGMP were all reduced in both the ZnPP IX and L-NAME groups as compared with the control group (P < 0.05).</p><p><b>CONCLUSION</b>ZnPP IX and L-NAME can reduce the concentrations of CO and NO in the penile tissues of rats, and consequently the content of cGMP.</p>
Full text:
1
Index:
WPRIM
Main subject:
Penis
/
Pharmacology
/
Protoporphyrins
/
Carbon Monoxide
/
Rats, Wistar
/
Cyclic GMP
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NG-Nitroarginine Methyl Ester
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Metabolism
/
Nitric Oxide
Limits:
Animals
Language:
Zh
Journal:
National Journal of Andrology
Year:
2009
Type:
Article