Ningbo thyroid dysfunction prevalence study: a cross-sectional survey in an employees-cohort / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1673-1678, 2010.
Article
in English
| WPRIM
| ID: wpr-241740
ABSTRACT
<p><b>BACKGROUND</b>The prevalence and the spectrum of thyroid dysfunction in the mainland of China are not adequately understood. We performed a population-based study to determine the prevalence of major thyroid dysfunctions including overt and subclinical hyper- and hypothyroidism in a stable cohort.</p><p><b>METHODS</b>All active and retired employees aged 20 years and older (11 067) of Sinopec Zhenhai Refining & Chemical Company in Ningbo participated in the cross-sectional survey with a questionnaire and blood samples.</p><p><b>RESULTS</b>A total of 10 405 individuals attended for screening. Using biochemical definitions 95.5% were euthyroid. The prevalence of former diagnosed hyperthyroidism was 1.1% in females and 0.4% in males, hypothyroidism 1.7% and 0.3%, and thyroid surgery 1.2% and 0.3%, respectively. In both sex the prevalence increased with age. Twenty-four percent of individuals with thyroid surgery or medications had abnormal thyroid-stimulating hormone (TSH) levels. In individuals without a history of thyroid disease, the prevalence of pathological TSH values in females and males were TSH > or = 10 mU/L 0.60% and 0.29%; TSH 4.8-9.9 mU/L 5.71% and 2.25%; TSH < 0.3 mU/L 0.87% and 0.41%, respectively. Overt hyper- and hypothyroidism were uncommon (0.2%, 0.3%, respectively). The prevalence of subclinical hyper- and hypothyroidism was 0.4% and 3.4%, respectively. Subclinical hypothyroidism was more common in females (male 2.4% vs. female 5.8%, P < 0.001) and with increasing age (P < 0.001).</p><p><b>CONCLUSIONS</b>The prevalence of thyroid dysfunction is 4.5% in the cohort. Among individuals with thyroid medications or surgery, only 75.7% were within the normal range of TSH. These results indicate that thyroid dysfunction is common in Chinese adults.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Diseases
/
Thyroid Function Tests
/
Thyrotropin
/
Epidemiology
/
Cross-Sectional Studies
/
Surveys and Questionnaires
/
Hyperthyroidism
/
Hypothyroidism
/
Metabolism
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2010
Type:
Article
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