Frequencies of high-resolution HLA-Cw* alleles in China Northern Han population / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 486-489, 2010.
Article
in Zh
| WPRIM
| ID: wpr-243328
Responsible library:
WPRO
ABSTRACT
This study was purposed to investigate the frequencies of HLA-Cw* loci in China Northern Han population at gene level and to analyze the population genetic characteristics of HLA-Cw* alleles and distribution difference of gene frequency in regions. The high resolution genotyping for HLA-Cw* loci of 420 cases in China Northern Han population was performed by using PCR-SSP typing technique and their distribution regularity was analyzed statistically. The results showed that 30 HLA-Cw* alleles were detected, among which the frequency of Cw* 0102 (0.1776), 0702 (0.1217), 0602 (0.1150) were highest; other alleles with higher frequency were as follow in proper order: Cw* 0304, 0801, 0303, 0302, 0401, 1402. The rare observed HLA-Cw* 0506, 0810, 1510, 1601 and 1701 were detected firstly in this population. The statistical analysis indicated that the genotype distribution of HLA-Cw* loci coincides with the Hardy-Weinberg test. In conclusion, application of high resolution allele typing can accurately understand the distribution regularity and characteristics of HLA-Cw* alleles in China Northern Han population which provides the basis for research related with HLA-Cw* loci.
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
/
Haplotypes
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
/
China
/
Asian People
/
Alleles
/
Gene Frequency
/
Genetics
Limits:
Adolescent
/
Adult
/
Child
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Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article