Studies on association of HSL repeat polymorphism and aerobic endurance / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 93-96, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-243423
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between hormone sensitive lipase (HSL) gene polymorphism and aerobic endurance.</p><p><b>METHODS</b>The (CA)n repeats polymorphism genotypes in HSL intro 6 of 123 outstanding long distance runners and 127 controls of Han nationality in northern China were analyzed by PCR and Fluorescence labeled STR-genescan. Repeat polymorphisms were grouped according to segmentation point and alleles were divided into long or short chains. Chi-square test was used to analyze the frequency difference of allelic and genotypic between athlete and control groups.</p><p><b>RESULTS</b>(CA) n repeats polymorphism in HSL gene was total of 9 different repeat number of alleles, which composed of 25 different genotypes. The chi-square test result showed that when compared short and long chain alleles split by 4, there was a significant difference (P <0.05) of genotype distribution in 5/10 km group compared with control. Compared the rest groups with control, there was no significant difference.</p><p><b>CONCLUSION</b>Compared short and long chain alleles split by 4, the LL genotype of (CA)n of HSL was associated with aerobic endurance and it might be a molecular marker of elite 5/10 km long distance runners.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Endurance
/
Polymorphism, Genetic
/
Ethnicity
/
China
/
Polymerase Chain Reaction
/
Sterol Esterase
/
Alleles
/
Genetics
/
Genotype
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2015
Type:
Article
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