The protective effect of Yuyin Ruangan Decoction on experimental hepatic injury / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 76-79, 2015.
Article
in Zh
| WPRIM
| ID: wpr-243428
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effects of Yuyin Ruangan Decoction(YRD, traditional Chinese medicine) on experimental hepatic injury in mice.</p><p><b>METHODS</b>The mice were randomly divided into control group, model group and YRD low, middle and high dose group(n = 11). By ip injection of D-GalN, CCk or thioacetamide (TAA), three models of hepatic injury mice were established to investigate the effects of YRD through detecting the indexes of liver function in serum and, the content of antioxidant system in the hepatic tissue.</p><p><b>RESULTS</b>YRD could decrease the content of alanine aminotransferase (ALT)and aspartate aminotransferase (AST) in serum and that of malonaldehyde (MDA) in the hepatic tissue, upregulate the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hepatic tissue. Furthermore, the above effects were dosedependent in a certain degree. CoNCLUSION:
YRD has some protection effects on the model of experimental hepatic injury in mouse.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Aspartate Aminotransferases
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Superoxide Dismutase
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Blood
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Drugs, Chinese Herbal
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Alanine Transaminase
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Drug Therapy
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Chemical and Drug Induced Liver Injury
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Glutathione Peroxidase
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Liver
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Applied Physiology
Year:
2015
Type:
Article