Identification of a new sildenafil analogue based on Q-TOF-MS / 药学学报
Acta Pharmaceutica Sinica
; (12): 513-516, 2014.
Article
in Zh
| WPRIM
| ID: wpr-245053
Responsible library:
WPRO
ABSTRACT
The drugs such as sildenafil adulterated in herbal products and dietary supplements may endanger human health. The number of the new modified derivatives is increasing recently. Based on Q-TOF-MS, a new sildenafil analogue was found. It was isolated and purified by preparative liquid chromatography. Its structure was determined by NMR, as 1-[4-propoxy-3-(6, 7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4, 3-d] pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine. Compared with sildenafil, the ethoxy group of the benzene ring moiety was moved to the propoxy group, which had not been reported in China. The mass spectrometric behavior pattern of the structure type was summarized, which can greatly accelerate the structural analysis of novel analogues.
Full text:
1
Index:
WPRIM
Main subject:
Piperazines
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Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
Drug Contamination
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Chromatography, High Pressure Liquid
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Dietary Supplements
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Spectrometry, Mass, Electrospray Ionization
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Sildenafil Citrate
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2014
Type:
Article