Preparation of inclusion complex of paeonol and beta-cyclodextrin by sealed-control temperature method / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>In the present study, using paeonol as model drug, a new sealed-control temperature method of preparing inclusion complex was developed, the effects of heating temperature, heating time, and crystallinity of beta-cyclodextrin (beta-CD) on formation of inclusion complex and release of the drug were investigated.</p><p><b>METHOD</b>A physical mixture of paeonol and beta-CD was sealed in a container, and heated at the desired temperature for the specified time. The inclusion complex of paeonol and beta-CD was confirmed by IR spectrum and powder X-ray diffraction.</p><p><b>RESULT</b>The results indicated that the inclusion complex formation of paeonol beta-CD by sealed-control temperature method was affected by heating temperature, heating time, and crystallinity of beta-CD. The inclusion complex was able to inhibit sublimation of paeonol, and dissolution rate of paeonol was increased when the paeonol was included by beta-CD.</p><p><b>CONCLUSION</b>Preparation of inclusion complex was simple and quick by sealed-control temperature method.</p>