Clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 460-462, 2011.
Article
in Zh
| WPRIM
| ID: wpr-246212
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation.</p><p><b>METHODS</b>275 patients with hepatitis B virus--related acute-on-chronic liver failure were investigated. The patients were divided into familial aggregation and non-familial aggregation group basis on their epidemiological features. Clinical data and biochemical indicators between the two groups were analyzed statistically.</p><p><b>RESULTS</b>93 of 275 patients (33.82%) case were family aggregation. There was no significant difference compared with chronic hepatitis B patients (38.3%). The mean age of the two groups was 45.98 and 43.61 years old, respectively (P > 0.05). The rates of liver cirrhosis in family aggregation group were significant higher than non-familial aggregation group (73.91% vs 58.24%, p < 0.05). Serum total (TBil) and prothrombin activities (PTA) were no significant difference between the two groups, but ALT level in familial aggregation group was much higher (407.80 U/L vs 256.45 U/L, P 0.05).</p><p><b>CONCLUSION</b>Familial aggregation were not related to acute-on-chronic liver failure in chronic HBV hepatitis patients. But the rate of liver cirrhosis were higher in patients with familial aggregation.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
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Family
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Acute Disease
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Epidemiology
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Alanine Transaminase
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End Stage Liver Disease
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Genetics
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Hepatitis B
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Liver Cirrhosis
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2011
Type:
Article