Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity / 药学学报
Acta Pharmaceutica Sinica
; (12): 263-267, 2010.
Article
in Zh
| WPRIM
| ID: wpr-250632
Responsible library:
WPRO
ABSTRACT
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Chemistry
/
Quinolones
/
HIV Integrase Inhibitors
/
HIV Integrase
/
Inhibitory Concentration 50
/
Metabolism
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article