The role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and the inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 205-214, 2010.
Article
in Zh
| WPRIM
| ID: wpr-250640
Responsible library:
WPRO
ABSTRACT
The late stages of the HIV-1 replication cycle are important to the overall replication cycle. During the late stages, HIV-1 replication undergoes the processes of assembly, release, and maturation, resulting in the production of a mature virus particle capable of infecting a new target cell. The structural protein Gag and its related gene (protein) play a central role in these pathways. The different regions of Gag worked in concert to drive production of a mature infectious particle through protein-protein, protein-RNA and protein-lipid interactions. The designed drug aimed directly at these stages can efficiently block the maturation and infectivity of HIV-1. In this article, the role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and related inhibitors is reviewed.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Phenylurea Compounds
/
Physiology
/
Piperidines
/
Succinates
/
Sulfur Compounds
/
Triterpenes
/
Virus Replication
/
Genes, gag
/
Chemistry
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2010
Type:
Article