Prophylactic administration of Yunnan Baiyao capsule reduces intra-operative blood loss in orthognathic surgery / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 542-545, 2008.
Article
in Zh
| WPRIM
| ID: wpr-251007
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the haemostatic efficacy and safety of prophylactic oral administration of Yunan Baiyao capsules on reduction of blood loss in bimaxillary orthognathic surgery.</p><p><b>METHODS</b>Eighty-seven patients scheduled for Le Fort I osteotomy and bilateral sagittal split ramus osteotomy (BSSRO) were enrolled in the prospective, randomized, double-blind, placebo-controlled clinical study. Forty-three patients took prophylactic oral administration of Yunnan Baiyao capsules 3 days before operation, and 44 patients without Yunnan Baiyao administration served as control. The intraoperative blood loss during Le Fort I osteotomy and bilateral sagittal split ramus osteotomy was estimated and the safety of Yunnan Baiyao capsules was evaluated.</p><p><b>RESULTS</b>The total blood loss in the Yunnan Baiyao group (330.5 +/- 134.4) ml was significantly lower than that of the control group (420.3 +/- 175.9) ml. The blood loss of Le Fort I osteotomy in the Yunnan Baiyao group (154.9 +/- 84.3) ml was also significantly lower than that of the control group (203.8 +/- 98.1) ml. The mean blood loss of BSSRO in the Yunnan Baiyao group was also lower than that of the control group, but the differences was not significant. The post-operative fibrinolysis was in the same level in both groups. Thromboemblic events or other side effects were not observed in this clinical trial.</p><p><b>CONCLUSIONS</b>Prophylactic oral administration of Yunnan Baiyao capsules can effectively reduce the intra-operative blood loss in bimaxillary orthognathic surgery. Yunnan Baiyao capsule are an effective and safe haemostatic traditional Chinese medicine.</p>
Full text:
1
Index:
WPRIM
Main subject:
Drugs, Chinese Herbal
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Double-Blind Method
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Prospective Studies
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Blood Loss, Surgical
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Therapeutic Uses
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Orthognathic Surgery
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Phytotherapy
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Methods
Type of study:
Clinical_trials
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Observational_studies
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Stomatology
Year:
2008
Type:
Article