Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol / 药学学报
Acta Pharmaceutica Sinica
; (12): 260-263, 2003.
Article
in Zh
| WPRIM
| ID: wpr-251129
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.</p><p><b>METHODS</b>Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.</p><p><b>RESULTS</b>Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.</p><p><b>CONCLUSION</b>Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Enoxacin
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Molecular Structure
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Ciprofloxacin
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Microbial Sensitivity Tests
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Norfloxacin
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Chemistry
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Combinatorial Chemistry Techniques
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Escherichia coli
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Methods
Limits:
Animals
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2003
Type:
Article