PTPN22 1858C/T polymorphism is associated with rheumatoid arthritis susceptibility in Caucasian population: a meta-analysis / 浙江大学学报·医学版
Zhejiang Daxue xuebao. Yixue ban
; (6): 466-473, 2014.
Article
in Zh
| WPRIM
| ID: wpr-251679
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of 1858C/T polymorphism of protein tyrosine phosphatase nonreceptor type 22 (PTPN22) and rheumatoid arthritis (RA) susceptibility.</p><p><b>METHODS</b>CMB, wanfang (Chinese) and PubMed databases were searched to get the studies on the association between 1858C/T polymorphism and RA susceptibility, and odds ratio (OR) and 95% confidential interval (CI) were calculated under different genetic models. Then heterogeneity, stratified analysis, and publication bias test were conducted in the study.</p><p><b>RESULTS</b>A total of 32 studies (40 separate comparisons) with 25 059 RA patients and 25 466 controls were included in this meta-analysis. No evidence for publication bias was found in these studies. Meta-analysis showed an association between PTPN22 1858C/T polymorphism and RA (OR=1.606, 95%CI: 1.518-1.699, P<0.001). When stratified by ethnicity, T allele of PTPN22 1858C/T polymorphism was a risk allele in Caucasian (OR=1.612, 95%CI: 1.544-1.683, P<0.001); however, the polymorphism was not detected in Asians (or allele frequencies was extremely low). PTPN22 1858C/T polymorphism was associated with rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (ACCP).</p><p><b>CONCLUSION</b>T allele of PTPN22 1858C/T polymorphism is associated with RA susaptibility in Caucasians. PTPN22 1858C/T polymorphism is significantly more prevalent in RF-positive or ACCP-positive patients than in RF-negative or ACCP-negative patients.</p>
Full text:
1
Index:
WPRIM
Main subject:
Arthritis, Rheumatoid
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Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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White People
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Protein Tyrosine Phosphatase, Non-Receptor Type 22
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Genetics
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
Zh
Journal:
Zhejiang Daxue xuebao. Yixue ban
Year:
2014
Type:
Article