Studies on bioactive constituents of whole herbs of Vernonia cinerea / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1986-1988, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-252157
ABSTRACT
<p><b>OBJECTIVE</b>To study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model.</p><p><b>METHOD</b>The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.</p><p><b>RESULT</b>Four compounds were identified to be (+)-lirioresinol B (1), stigmasterol (2), stigmasterol-3-O-beta-D-glucoside (3), 4-sulfo-benzocyclobutene (4), and their NGF inducing activity were also investigated.</p><p><b>CONCLUSION</b>Compounds 1, 3, 4 were isolated from this genus for the first time, and compound 4 was identified as a new natural product. Compounds 1, 3, 4 showed cytotoxicity on PC-12, and compounds 2, 3, 4 showed inhibition activity. Compound 4 showed a specific effect on the survival of TrkA fibroblasts, and resulted in the inducing NGF activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polycyclic Compounds
/
Stigmasterol
/
Drugs, Chinese Herbal
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Chemistry
/
PC12 Cells
/
Vernonia
/
Glucosides
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article
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