Study on amplification of ZNF217 in primary gastric carcinoma / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 60-62, 2005.
Article
in Zh
| WPRIM
| ID: wpr-252464
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate amplification of zinc finger protein 217(ZNF217) and its association with clinicopathologic parameters in primary gastric carcinoma.</p><p><b>METHODS</b>Semiquantitative polymerase chain reaction (PCR) was used to determine DNA copies of ZNF217 in the specimens from forty- seven cases with primary gastric carcinoma.</p><p><b>RESULTS</b>There was no difference in DNA copies between tumor specimens and paratumor normal tissues. The incidence of ZNF217 amplification was 11.36% in gastric cancer. The amplification of ZNF217 was significantly associated with tumor size(P< 0.01) and intestinal type of stomach cancer(P< 0.05).</p><p><b>CONCLUSION</b>Oncogene ZNF217 may play a role in specific tumor types or subtypes of gastric cancer. There may be other oncogenes associated with gastric carcinoma in 20(q)13.</p>
Full text:
1
Index:
WPRIM
Main subject:
Stomach Neoplasms
/
DNA, Neoplasm
/
Trans-Activators
/
Gene Amplification
/
Genetics
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2005
Type:
Article