Studies on anti-tumor metastatic constituents from Lindera glauca / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1032-1036, 2011.
Article
in Zh
| WPRIM
| ID: wpr-252948
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the anti-tumor metastatic constituents from Lindera glauca.</p><p><b>METHOD</b>Constituent isolation and purification was carried by repeated column chromatography (silica gel, Toyopearl HW-40 and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. The anti-tumor metastasis assay was applied to evaluate the isolated compounds of their activities.</p><p><b>RESULT</b>Ten compounds (1 - 10) were isolated and their structures were identified by comparison of their spectral data with literature values as follows Laurotetanine (1), N-methyllaurotetanine (2), reticuline (3), pallidine (4), N-trans-feruloyltyramine (5), N-cis-feruloyltyramine (6), atheroline (7), norisosocorydine (8), [9,9,9-(2) H3]-(1S*, 3S*, 4S*, 8S*)-p-menthane-3,8-diol (9), [9,9,9-(2) H3 ]-(1S*, 3R*, 4S*, 8S*)-p-Menthane-3,8-diol (10). Compounds 1, 2, 4, 5, 7 and 9 showed positive anti-tumor metastatic activities,and compounds 1, 4, and 5 showed significant anti-tumor metastatic activities.</p><p><b>CONCLUSION</b>Compound 3 was isolated from this plant for the first time. Compounds 9 and 10 were isolated from Lindera genus for the first time. Compounds 1, 4, and 5 showed significant anti-tumor metastatic activities.</p>
Full text:
1
Index:
WPRIM
Main subject:
Aporphines
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Plant Extracts
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Chemistry
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Chromatography, High Pressure Liquid
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Lindera
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Monoterpenes
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Cell Line, Tumor
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Benzylisoquinolines
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Alkaloids
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Methods
Limits:
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article