Parallel catalytic hydrogen wave of acetylspiramycin caused by dissolved oxygen and its application / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1135-1138, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-253516
ABSTRACT
<p><b>AIM</b>To propose a novel polarographic method for the determination of acetylspiramycin (ASPM) is proposed.</p><p><b>METHODS</b>In 0.1 mol x L(-1) NH4Cl-NH3 x H2O (pH 8.9) buffer containing dissolved oxygen, ASPM yielded a sensitive parallel catalytic hydrogen wave with the peak potential of -1.63 V (vs SCE) by single sweep polarography.</p><p><b>RESULTS</b>The 2nd order derivative peak currents (i(p)") of the parallel catalytic hydrogen waves of ASPM showed a linear relationship with its concentrations in the range from 1.74 x 10(-3) microg x mL(-1) to 3.84 microg x mL(-1) (r = 0.9979, n=13). Its detection limit was 5.80 x l0(-4) microg x mL(-1) (3sigma) and RSD (n=13) was 1.24% at the concentration level of 0.871 microg x mL(-1).</p><p><b>CONCLUSION</b>The proposed method could be applied to the determination of ASPM in ASPM tablets.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Polarography
/
Tablets
/
Catalysis
/
Spiramycin
/
Chemistry
/
Reproducibility of Results
/
Hydrogen
/
Hydrogen-Ion Concentration
/
Methods
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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