Capecitabine combined with TACE for advanced liver cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 565-566, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-254299
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the clinical efficacy of capecitabine combined with transcatheter arterial chemoembolization (TACE) for advanced liver cancer.</p><p><b>METHODS</b>Forty-nine patients with liver cancer were retrospectively divided into two groups Treatment group, on the basis of TACE, 23 patients received oral capecitabine at 2500 mg/m(2), twice-daily for 14 days followed by 7-day rest period and repeated in every three week intervals for more than two cycles. Control group, 26 patients received TACE only at 2-month intervals for at least two cycles.</p><p><b>RESULTS</b>In capecitabine and TACE group there were 1 CR, 14 PR, 5 SD and 3 PD; the overall response rate was 65.2%; the AFP and tumor reduction rates were 68.8% and 73.9%; the median survival time was 11.9 months. In the TACE only group there were 0 CR, 7 PR, 12 SD and 7 PD; the overall response rate was 26.9%; the AFP and tumor reduction rates were 31.6 % and 30.8%; the median survival time was 8.3 months. The most common side-effects of capecitabine were hand-foot syndrome and diarrhea.</p><p><b>CONCLUSION</b>Capecitabine combined with TACE is safe and effective for advanced liver cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Drug Administration Schedule
/
Administration, Oral
/
Mitomycin
/
Chemoembolization, Therapeutic
/
Combined Modality Therapy
/
Deoxycytidine
/
Capecitabine
/
Fluorouracil
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2004
Type:
Article
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