Interaction between an insertion/deletion polymorphism in pepsinogen C and Helicobacter pylori infection in the development of gastric cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 644-648, 2008.
Article
in Zh
| WPRIM
| ID: wpr-255611
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study was designed to investigate the interaction between pepsinogen C(PGC) insertion/deletion polymorphism and Helicobacter pylori(Hp) infection, together with its different subtype strains, in the development of gastric cancer (GC).</p><p><b>METHODS</b>PGC Genotypes were determined by polymerase chain reaction (PCR) assay in 564 subjects with superficial gastritis (NOR), gastric ulcer (GU), atrophic gastritis (AG) and GC, who were frequency-matched as 1:1. Serum Hp-IgG antibodies were determined by an enzyme linked immunoadsorbent assay (ELISA). Hp genetic subtypes in 171 patients with Hp infection were determined by PCR methods.</p><p><b>RESULTS</b>In GU, AG and GC, the OR of interaction was 8.69 (P = 0.049), 11.16 (P = 0.02), and 10.61 (P = 0.03), respectively; the interaction index of PGC homozygous allele 1 genotype and Hp infection was 5.40, 6.48 or 4.34, respectively; the attributable proportions were 0.721, 0.770 and 0.697, respectively. In AG and GC, no significant interactions were observed between PGC polymorphism and Hp genetic subtypes.</p><p><b>CONCLUSION</b>The findings of this study suggest that PGC insertion/deletion polymorphism and Hp infection seem to present a positive interaction in the development of gastric cancer. While no interactions may be present between PGC polymorphism and Hp genetic subtypes.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Stomach Neoplasms
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Stomach Ulcer
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Virulence
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Molecular Sequence Data
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Base Sequence
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Helicobacter pylori
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Helicobacter Infections
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Genetic Predisposition to Disease
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Pepsinogen C
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Oncology
Year:
2008
Type:
Article