Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea
Immune Network
;
: 311-315, 2016.
Article
in English
| WPRIM
| ID: wpr-25613
ABSTRACT
A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthomyxoviridae
/
Ovum
/
Swine
/
Influenza Vaccines
/
Cell Line
/
Agriculture
/
Eggs
/
Influenza, Human
/
Pandemics
/
Seroconversion
Limits:
Animals
Country/Region as subject:
Asia
Language:
English
Journal:
Immune Network
Year:
2016
Type:
Article
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