Effects of selenium and zinc on rat renal apoptosis and change of cell cycle induced by fluoride / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 219-221, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-257263
ABSTRACT
<p><b>OBJECTIVE</b>This study was conducted to study the effects of sodium fluoride (NaF) on rat renal apoptosis and proliferation, the antagonistic effect of selenium-zinc preparation (Se-Zn) to NaF.</p><p><b>METHODS</b>Wistar rats were provided with distilled water containing NaF (50 mg/L) and administered by gavage with different dosed of Se-Zn for six months. Kidney cell apoptosis and the cell cycle of proliferation were detected by TUNEL (TdT-mediated dUTP Nick End Labelling) and flow cytometry.</p><p><b>RESULTS</b>NaF caused rat renal apoptosis, reduce the cell number of G(2)/M period in cell cycle and decrease the relative content of DNA significantly. Se-Zn inhibited the effects of NaF on apoptosis and increased the cell number of G(2)/M period in cell cycle, but failed to increase relative content of DNA.</p><p><b>CONCLUSION</b>It was suggested that NaF could induce apoptosis and change the cell cycle in rat renal cells and Se-Zn could antagonize apoptosis and the changes of cell cycle induced by NaF.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Selenium
/
Sodium Fluoride
/
Zinc
/
DNA
/
Cell Cycle
/
Cell Division
/
Apoptosis
/
In Situ Nick-End Labeling
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2002
Type:
Article
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