Advances in research of the mechanism of "covert disorder" in diabetic skin / 中华烧伤杂志
Chinese Journal of Burns
; (6): 51-53, 2012.
Article
in Zh
| WPRIM
| ID: wpr-257815
Responsible library:
WPRO
ABSTRACT
The diabetic ulceration is not uncommon, and becomes refractory, as the skin in a diabetic patient is relatively thin as well as hypoesthetic and less sensitive to temperature. As there are already preexisting histological and cellular derangement in the skin, healing of the skin injury is difficult, thus resulting in an intractable ulceration. When diabetes is not controlled, the skin contents of sugar and advanced glycation end product accumulate, invoking cellular deformation and accumulation of matrix metalloproteinases (MMP), resulting in an imbalance between MMP and its inhibitors, malfunction of growth factors, and inflammatory reaction. These processes lead to obvious skin thinning, denaturation of connective tissues, thickening of vascular basal membrane, and neuropathy, etc. These pathological alterations could be recognized as "covert disorder" of skin in diabetic patients and may be underlying disorders in producing indolent diabetic ulcers.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Skin
/
Skin Ulcer
/
Wound Healing
/
Glycation End Products, Advanced
/
Diabetes Mellitus
/
Metabolism
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Burns
Year:
2012
Type:
Article