Expressions of CD1a and CD83 of Langerhans cells in the local lesions of epidermodysplasia verruciformis patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 17-19, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-259085
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of CD1a and CD83 of Langerhans cells (LC) in the lesions of epidermodysplasia verruciformis (EV) patients.</p><p><b>METHODS</b>We used immunohistochemical method to detect the expressions of CD1a and CD83 in the lesions of 10 patients with EV lesions and in the skins of 10 normal subjects.</p><p><b>RESULTS</b>No CD83 + LCs was detected in all EV patients and normal controls, but CD1a + LC was found in all cases. The quantity of CD1a + LCs in the lesions of EV patients was significantly lower than that in the normal skin (P < 0.01); furthermore, the distribution of LCs in EV lesions was uneven.</p><p><b>CONCLUSION</b>The functions of LCs may be inhibited in EV patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Skin
/
Epidermodysplasia Verruciformis
/
Receptors, Immunologic
/
Antigens, CD
/
Langerhans Cells
/
Antigens, CD1
/
Allergy and Immunology
/
Leukocyte Immunoglobulin-like Receptor B1
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2009
Type:
Article
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