Design, synthesis and biological evaluation of novel diaryl ethers bearing a pyrimidine motif as human Pin1 inhibitors / 药学学报
Acta Pharmaceutica Sinica
; (12): 1266-1272, 2013.
Article
in Zh
| WPRIM
| ID: wpr-259484
Responsible library:
WPRO
ABSTRACT
Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) belongs to peptidyl-prolyl cis-trans isomerase (PPIase) and is a novel promising anticancer target. Based on the lead structure of benzophenone, a series of novel diarylether derivatives containing a pyrimidine ring were designed and synthesized. The inhibitory activities on Pin1 of compounds 5a-5d and 6a-6i were evaluated by a protease-coupled enzyme assay. Of all the evaluated compounds, 6 compounds displayed inhibitory activities. Molecular docking was performed using FlexX algorithm to explore the binding mode of the active molecules.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Pyrimidines
/
Structure-Activity Relationship
/
Drug Design
/
Molecular Structure
/
Chemistry
/
Peptidylprolyl Isomerase
/
Inhibitory Concentration 50
/
Enzyme Inhibitors
/
Ethers
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2013
Type:
Article